The expression of peptide growth factors in hemangioma and its clinical significance
Abstract：Objective: To understand the relationship between peptide growth factors and hemangioma(H).Methods: The expression of bFGF, bFGFR, TGF-β and EGF was examined by immunohistochemistry in the tissue sections from98 cases with Hand 32 cases with vascular malformation(VM). Results: ①The expression of bFGF and bFGFR was high in H and low in VM( P < 0.01 ). ②There was definite relation between the expression of bFGF and bFGFR and the proliferative degree of endothe-lial cells,more proliferation of endothelial cells, the higher expression of bFGF and bFGFR(P<0.01). The expression ofbFGF was positively corelated to the expression of bFGFR in H. ③Both TGF-β and EGF did not express in H and VM. Con-clusion: bFGF and bFGFR are definitely related to proliferation and involution of H.
Keywords：growth factorhemangiomavascular malformationimmunohischemistry
Publication Date：2000-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：2( 132-133 )