Experimental study on hepatic toxic injury induced by ofloxacin with Antituberculosis drugs in mice
Abstract：Objective: To study hepatic toxic injury induced by ofloxacin with Antituberculosis drugs in mice. Methods: Thelevel of serum glutamic-pyruvic transaminase(ALT), liver index, content of malondialdehyde (MDA) of liver homogenate, activity of hepatic microsome enzyme and mitochondrial membrane Ca2 + -ATP enzyme,and degree of liver cell injury were investigated in mice which are in control group and the experimental groups of isoniazid ( I ), rifampicin (R), combining isoniazidwith rifampicin(IR), combining ofloxacin with isoniazid and rifampicin(IRO). Results: The groups of IR, IRO could markedlyincrease the level of ALT, and content of MDA of liver homogenate ( P < 0.05) and decrease the activity of mitochondrialmembrane Ca2 +-ATP enzyme ( P > 0.05),but IRC doesn＇t induced these alterations. IR, IRO could increase the degree of liver injury,but there was no difference among the groups of IR,IRO. Conclusion: Combination ofloxacin with isoniazid and rifampicin in mice increase hepatic toxic injury, but the level of injury was little lower than combination isoniazid with rifampicin.
Keywords：ofloxacinhepatic toxic injurylipid peroxidationmitochondrial membrane Ca2 + -ATP enzyme
Publication Date：2000-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 125-127 )