Comparison of the effects of fenoldopam on the cAMP generating system in rabbit mesenteric and pulmonary arteries
ZHU Lin
ZHAO Rong-rui
LI Liang-chen
Abstract：Objective: To evaluate and compare the effects of DA1 receptor agonist,fenoldopam,rabbit pulmonary and mesen-teric arteries. Methods: Using radioimmunoassay determined effects of fenoldopam on the cAMP generating system in rabbitmeaenteric and pulmonary arteries. Results: The selective DA1-receptors agonist, fenoldopam, induced a dose-related increasescAMP formation in mesenteric and pulmonary arteries; however, them agnitude of increase in the mesenteric artery was re-markably greater than that in the pulmonary artery. The selective DA1-receptors antagonist,SCH23390,blocked fenoldopam-in-duced cAMP production, while the selective DA2-receptors antagonist, domperidone, was without effect on the increase of cAMPelicited by fenoldopam. Conclusion: The presence of DA1-receptors associated with stimulation of AC activity in both mesen-teric and pulmonary arteries. However, there are much fewer receptor sites in the pulmonary artery than in mesenteric artery,suggesting less physioloieal importace of such recePtors in the pulmonary artery than in the mesenteric artery.
Keywords：cyclic AMPpulmonary arteryrenal arteryfenoldopamSCH23390
Publication Date：2000-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 122-124 )