Research Progress in Genome and Diagnostic Methods of Porcine Epidemic Diarrhea Virus
ZHANG Yuyang
Abstract：Porcine epidemic diarrhea(PED)caused by porcine epidemic diarrhea virus(PEDV)is an acute,highly contagious,enteric disease of pigs with high morbidity and mortality,thereby bringing huge economic losses to the pig industry all over the world.A better understanding of PEDV's genome and function is key to developing an effective and safe vaccine.By understanding PEDV's genomic structure,the proteins it encodes,and its interactions with host cells,researchers can design more targeted vaccine candidates.Advances in PED diagnostic technology are essential for early diagnosis and monitoring and evaluation of post-immune response.In this review,we summarized the latest progress of PEDV genome structure and function including S,E,M,N,accessory proteins and non-structural proteins,serology and molecular diagnostic methods,such as enzyme-linked immunosorbent assay,polymerase chain reaction,ring-mediated isothermal amplification,viral neutralization and indirect immunofluorescence assays,immunochromatographic tests,fluorescent microsphere immunoassays,sequence assays and clustered regularly inter spaced short palindromic repeats(CRISPR)-Cas,in order to provide ideas for establishing rapid and effective PEDV detection methods,and provide reference for effective prevention and control of PED in practice.
Keywords：PEDVPEDGenomeDiagnosis
Publication Date：2024-10-15
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：9( 12-20 )