Effects of Chlorantraniliprole on Sodium Channel Currents of Central Neurons from L aphygma exigua
GUO Zhiyue
WANG Guohong
ZHEN Jing
HE Bingjun
Abstract：In order to study the insecticidal mechanism of the new insecticide chlorantraniliprole on Laphygma exigua ,the effects of chlorantraniliprole on sodium channel currents of acutely isolated central neurons from Laphygmaexigua were studied using whole-cell patch clamp tech-nique .The results showed that after application of chlorantraniliprole (0 .1 g/L ) ,the current spike was (-9 .627 ± 0 .114) nA in 1 minute ,(-11 .668 ± 0 .131) nA in 5 minutes ,(-8 .726 ± 0.398) nA in 15 minutes .In current clamp mode ,after application of the drug (0 .4 g/L ) the ac-tion potential spike was (94 .366 ± 4 .596) mV in 1 minute ,(90 .363 ± 2 .258) mV in 3 minutes , (83 .15 ± 2 .959) mV in 5 minutes .The duration was prolonged from (5 .025 ± 0 .884) ms in 1 mi-nute to (6 .032 ± 0 .073) ms in 3 minutes to (6 .387 ± 0 .376) ms in 5 minutes .After 10 min of drug action ,only electric tension was produced ,with no action potential .The results indicated that chlorantraniliprole changed the inward sodium current in a concentration-dependent manner .After treatment with the drug of 0 .1 g/L ,the current peak was increased in the beginning ,and then re-duced slowly .The decrease of action potential spike and the extension of the duration maybe re-sult from the inhibition effects of chlorantraniliprole on the sodium currents .In conclusion ,the so-dium channel in central neurons of Laphygmaexigua was one of the action targets of chlorantra-niliprole .
Keywords：chlorantraniliproleLaphygmaexiguacentral neuronsodium channelpatch clamp technique
Publication Date：2013-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 79-83 )