Protective Effect of Modified Yupingfeng Powder Combined with Guizhi Decoction on the Personnel Rapidly Ascending to Plateau

ZHANG Rui; YANG Junling; YAN Zhongsheng; YAN Xiangyong; NIU Xiaojuan; LI Jun

doi:10.13730/j.issn.2097-2148.2025.11.010

Abstract：Objective To observe the protective effect of modified Yupingfeng powder combined with Guizhi decoc-tion on acute high altitude illness(AHAI)in personnel rapidly ascending to plateau.Methods A total of 90 male officers and soldiers from the troops that were urgently dispatched to the plateau region for training in 2022 were recruited and randomly divided into modified Yupingfeng powder combined with Guizhi decoction group(modified Yupingfeng powder group),Rhodiola group and Acetazolamide group,with 30 participants in each.The modified Yupingfeng powder group and the Rhodiola group took Yupingfeng powder granules and rhodiola capsules orally for 14 d,respectively,7 d before entering plateau,the Acetazolamide group took Acetazolamide tablets orally for 4 d,24 h before entering plateau.The differences of blood pressure,heart rate,blood oxygen saturation,incidence and severity of AHAI,inflammatory index,immunoglobulin M(IgM),neutrophil count and drug safety index were compared among the three groups on the 1st(D1),3rd(D3)and 7th days(D7)after sta-tioned at plateau.Results The modified Yupingfeng pow-der group showed significantly higher blood oxygen satu-ration and lower heart rate and blood pressure compared to the other two groups at each timing(all P＜0.05).There was a statistically significant difference in the overall incidence rate of AHAI among the three groups(P＜0.05),and the in-cidence of AHAI was significantly lower in the modified Yupingfeng powder group than that in Rhodiola group(P＜0.05),however,there was no significant difference in the severity of AHAI among the three groups at each timing(P＞0.05).The interleukin 6(IL-6)level in the modified Yupingfeng powder group was lower than that in the other two groups on the D1 and D3,the IL-8,IL-1 β and tumor necrosis factor alpha(TNF-α)levels were significantly lower than those in the other two groups at each timing(all P＜0.05).The levels of IL-10 and IgM anti-inflammatory factors in the modified Yupingfeng powder group were significantly higher than those in the other two groups at each timing(all P＜0.05).The neutrophil count of participants in Acetazolamide group was lower than that of modified Yupingfeng powder group and Rhodiola group on D1(all P＜0.05).The incidence of adverse drug reactions in the modified Yupingfeng powder group and Acetazolamide group was higher than that in the Rhodiola group,and Acetazolamide group was higher than that in the Yupingfeng powder group(all P＜0.05).Conclusion Modified Yupingfeng powder combined with Guizhi decoction helps maintain the vital signs of personnel rapidly ascending to plateau,and it can significantly reduce incidence of AHAI,reduce the levels of inflammatory factors,enhance the body's immunity,which is relatively safe and has impor-tant clinical value for the prevention of AHAI.