Correlation Between Circulating Fibrocyte Levels and Infarct Size in STEMI Patients Treated with Primary Percutaneous Cor-onary Intervention
YIN Meijing
SONG Yafan
LI Wen
ZHENG Maomao
WANG Ni
Abstract：Objective To analyze the relationship between the levels of circulating fibrocyte(CF)and the infarct size of patients after primary percutaneous coronary intervention(pPCI)for ST-segment elevation myocardial infarction(STEMI).Methods A prospective study was conducted to enroll 103 patients with acute STEMI who underwent pPCI from January 2020 to February 2024,the infarct size at 1 week and 6 months after pPCI were examined by cardiac mag-netic resonance imaging,and CF levels were measured 1 week after pPCI.Results STEMI patients were divided into low CF group(CF＜5.46 × 105/ml,n=51)and high CF group(CF≥5.46 × 105/ml,n=52)with the median CF level of 5.46 × 105/ml as the critical value 1 week after pPCI.The incidence of major adverse cardiovascular events was higher in the high CF group(P＜0.001).The baseline infarct size proportion was 25.67％(16.09％,32.17％)in the low CF group and 25.30％(22.70％,29.48％)in the high CF group,respectively,with no significant difference(P=0.537).However,the infarct size in the low CF group was significantly smaller than that in the high CF group 6 months after sur-gery[25.90％(17.45％,32.20％)vs.32.40％(27.35％,36.60％),P=0.001].Spearman rank correlation analysis showed that only CF level was positively correlated with infarct size 6 months after surgery(r=0.363,P＜0.001).CF level predicted 0.838[95％confidence interval(CI):0.752-0.903]of subjects with infarct size ≥18％6 months after STEMI surgery.Conclusion Among STEMI patients treated with pPCI,postoperative CF levels are positively correlated with infarct size on cardiac magnetic resonance imaging at 6 months.CF levels can be used as a risk stratification tool or as a target for therapeutic response.
Keywords：Primary percutaneous coronary inter-ventionST-segment elevation myocardial infarctionCir-culating fibrocyteInfarct size
Publication Date：2025-08-28
Online Publishing Date：2025-09-18(First online date of this platform, not the publication date of the document)
Pages：6( 682-687 )