Correlation Between Serum Magnesium Concentration and Fracture in Maintenance Hemodialysis Patients

CHEN Ping; LU Xiaomei; YIN Shujun

doi:10.13730/j.issn.2097-2148.2025.07.009

Abstract：Objective To explore the relationship between serum magnesium concentration and fracture in maintenance he-modialysis(MHD)patients.Methods The clinical data of 207 patients who received MHD treatment in author's hospital from January 1,2015 to December 31,2020 were enrolled.Propensity score matching(PSM)was used to balance the baseline data of the two groups,and 57 patients in fracture group(all fractures occurred for the first time)and 57 patients in non-fracture group were included.Logistic regression analysis was used to explore the relationship between serum magnesium and fractures.Receiver operating characteristic(ROC)curve was used to analyze the predictive efficacy of serum magnesium for fracture in MHD pa-tients.Results Among 207 patients,the proportion of fracture was 27.54％(57/207),with hip fractures accounting for 52.63％(30/57),which was the most common type of fracture.After PSM matching,114 patients were finally included,inclu-ding 57 patients in the fracture group and 57 patients in the non-fracture group.The age and body mass index(BMI)levels of MHD patients in fracture group were higher than those in non-fracture group,and the serum magnesium concentration and calci-um concentration were lower than those in non-fracture group(all P＜0.05).Serum magnesium and calcium concentration were negatively correlated with fractures in MHD patients(P＜0.05),while age was positively correlated with fracture in MHD pa-tients(P＜0.05).Logistics regression analysis showed that for every 0.5 mmol/L increase in magnesium concentration,the risk of fracture in MHD patients decreased by 48.30％(OR=0.517,P=0.004);when serum magnesium concentration was used as a categorical variable,the risk of fracture in MHD patients in the high magnesium group decreased by 64.20％compared with the low magnesium group(OR=0.358,P=0.041).ROC curve analysis result showed that serum magnesium combined with age had good predictive effect on fracture in MHD patients[area under the curve(AUC)=0.744,P＜0.010].Conclusion Higher serum magnesium concentration is associated with lower risk of fracture in MHD patients,serum magnesium combined with age may help to predict the risk of fracture in MHD patients.