Correlation Between Peripheral Nerve Hypersensitivity and Body Fat Composition and Thyroid Function in Patients with Dia-betes Mellitus Type 2
ZHANG Bilin
HAN Pingping
ZHANG Yu
XIANG Shiqiang
XIANG Guangda
Abstract：Objective To analyze the effect of body fat composition and thyroid function on peripheral nerve hypersen-sitivity in patients with diabetes mellitus type 2(T2DM).Methods A total of 100 T2DM patients who received blood glu-cose management in the author's hospital from August 2020 to August 2021 were selected as the research objects.Accord-ing to the results of the sensory nerve quantitative detector,the patients with a normal range of fast section of range current perception threshold(R-CPT)were included in the control group(n=49),and the patients with lower R-CPT than the nor-mal range were included in the hyperesthesia group(n=51).Thyroid function in biochemical indicators,body composition analysis(body fat mass,body fat rate,visceral fat area and other indicators)and R-CPT were measured in the two groups of T2DM patients,the differences in body fat composition and thyroid function between the two groups were compared,and the correlation between 2 000,250,5 Hz R-CPT and body fat composition was analyzed.Results Body mass index(BMI),body fat mass,body fat rate,visceral fat area,trunk fat mass,lower limb fat mass and free thyroxine(FT4)in T2DM pa-tients with hyperesthesia were higher than those in control group(all P＜0.05).In T2DM patients,2 000 Hz R-CPT was negatively correlated with BMI,waist circumference,waist hip ratio,FT4,visceral fat area and HCY(P＜0.05),the 250 Hz R-CPT was negatively correlated with FT4(P＜0.05),there was no significant correlation between 5 Hz R-CPT and body composition indexes(P＞0.05).Logistic regression analysis showed that body fat mass and FT4 were risk factors for peripheral nerve hypersensitivity in T2DM patients(P＜0.05).Conclusion Obesity and high body fat composition are im-portant factors affecting the progression of peripheral neuropathy in T2DM patients in the early stage of neuropa-thy.
Keywords：Diabetes mellitus type 2Peripheral nerve hypersensitivityRange current perception thresh-oldEarly diagnosisObesityVisceral fat
Publication Date：2025-07-28
Online Publishing Date：2025-08-27(First online date of this platform, not the publication date of the document)
Pages：7( 590-595,606 )