Effect of Pioglitazone Metformin Combined with Cordyceps Sinensis Preparation on Serum Oxidative Stress and Renal Func-tion in Patients with Diabetic Nephropathy

HU Leiyuan; YANG Qianyong; HOU Beilei; XIONG Yadan

doi:10.13730/j.issn.2097-2148.2025.07.004

Abstract：Objective To analyze the effects on oxidative stress and renal function in patients with diabetic nephropa-thy treated with the combination of Pioglitazone Metformin and Cordyceps sinensis preparation.Methods A total of 125 patients with diabetic nephropathy treated in author's hospital from January 2021 to December 2023 were select-ed as research subjects.The patients were divided into con-trol group(n=59)and study group(n=66)according to different treatment programs.The diabetic nephropathy patients in the control group were treated with Metformin Hydro-chloride combined with Cordyceps sinensis preparation,and the diabetic nephropathy patients in the study group were treated with Pioglitazone Metformin combined with Cordyceps sinensis preparation.The general information,the differences of oxi-dative stress response indicators,renal function,blood glucose,inflammatory factors,hemorheological indicators,clinical efficacy and adverse reactions of patients with diabetic nephropathy before and after treatment were compared between the two groups.Results Before treatment,oxidative stress response indicators including oxidized low density lipoprotein choles-terol(OXLDL),malondialdehyde(MAD),glutathione peroxidase(GSH-Px),superoxide dismutase(SOD)levels,renal function indicators including urine trace albumin excretion rate(UAER),serum creatinine(Scr),Cystatin C(CysC),urea nitrogen(BUN)levels,blood glucose indicators including glycosylated hemoglobin A,c(HbA1c),2h postprandial blood glucose(2hPBG),fasting plasma glucose(FPG)levels,inflammatory factors including interleukin 17(IL-17),tumor nec-rosis factor alpha(TNF-α),transforming growth factor beta 1(TGF-β1),hypersensitive C-reactive protein(hs-CRP)levels,hemorheological indicators including high shear viscosity of whole blood(WBHSV),low shear viscosity of whole blood(WBLSV)and plasma viscosity(PV)levels were statistically significant(P＞0.05).After treatment,the levels of OXLDL and MAD in the two groups of diabetic nephropathy patients were significantly lower than those before treatment,and GSH-Px and SOD were significantly higher than those before treatment,and the improvement in the study group was more signifi-cant than that in the control group(all P＜0.05);renal function indicators including UAER,Scr,CysC and BUN levels,blood glucose indicators including HbA1c,2hPBG and FPG levels,inflammatory factors including IL-17,TNF-α,TGF-β1 and hs-CRP levels,and hemorheological indicators including WBHSV,PV and WBLSV levels in the two groups were signif-icantly lower than those before treatments,and the study group was lower than the control group(all P＜0.05).The total effective rate of the study group was higher than that of the control group(P＜0.05),but there was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combined treatment of Pioglita-zone Metformin and Cordyceps sinensis preparations in patients with diabetic nephropathy can effectively alleviate the oxida-tive stress response and inflammatory response,improve the renal function,effectively control the blood glucose,which has a good clinical efficacy for patients and can be widely promoted and applied in clinical applications.