Expression and Clinical Significance of Heat Shock Protein 70 in Serum of Hemophagocytic Lymphohistiocytosis in Children

LU Wenjie; WANG Zhuo; YANG Li; LONG Fei; CHEN Jingpei; SUN Ming; WANG Wei; ZHANG Lannan; XU Xiuwen; XIONG Hao

doi:10.13730/j.issn.2097-2148.2024.12.009

Abstract：Objective To explore the expression and clinical significance of heat shock protein 70(HSP70)in ser-um of hemophagocytic lymphohistiocytosis(HLH)in children.Methods Children who diagnosed with HLH at author's hospital from September 2019 to August 2021 were selected as the HLH group(n=12),Children with sepsis were se-lected as the sepsis group(n=45),while healthy children underwent routine physical examinations were selected as the control group(n=32).Additionally,HLH child patients who achieved remission following initial treatment were classi-fied as the remission group(n=11).The expression of HSP70 in serum of children in each group was detected,the levels of interleukin 6(IL-6),interleukin 10(IL-10),interferon gamma(IFN-γ)and lymphocyte subpopulation were assessed.Results The level of HSP70 in the HLH group was higher than that in sepsis group and control group(P＜0.001).The levels of IL-10 and IFN-γ in HLH group were higher than those in sepsis group and control group(P＜0.001).The IL-6 level was higher in the HLH group compared with control group(P＜0.001),but lower than that in the sepsis group while there was no statistical significance between the two groups(P＞0.05).The serum concentration of HSP70 in the HLH group was higher than that in the remission group(P＜0.001).Conclusion The serum concentration of HSP70 is higher in children with HLH compared with children with sepsis and health children,it suggests that HSP70 can serve as a potential novel biomarker for the early identification and differential diagnosis of HLH and sepsis in child patients.The combination analysis of HSP70,IL-10,and IFN-γoutcomes may facilitate the early evaluation of disease progression and severity in child patients with infectious symptoms.