Effect of Gabapentin Combined with Eszopiclone on Restless Leg Syndrome and Sleep Disorder in Hemodialysis Patients

LYU Yan; HUANG Yaoyu; MAO Ruizhi; BI Xiaofei; ZHAO Wei; TANG Xinfang

doi:10.13730/j.issn.2097-2148.2024.12.008

Abstract：Objective To evaluate the effectiveness of combining Gabapentin with Eszopiclone for managing restless leg syndrome(RLS)and sleep disorders in patients receiving maintenance hemodialysis(MHD).Methods A total of 64 MHD patients with RLS and sleep disorders in the author's hospital from October 2022 to March 2024 were selected as the study objects,they were divided into observation group and control group by random number table method,with 32 cases in each.The control group was given Gabapentin treatment,the observation group was treated by a combination of Gabapentin and Eszopiclone.The severity of RLS in both groups was evaluated by the international restless legs syndrome study group rating scale(IRLS),RLS symptoms and efficacy were compared between the two groups after treatment.The Hamilton anxiety scale 14(HAMA-14)and Hamilton depression scale 24(HAMD-24)were used to evaluate the anxiety and depression of the patients before and after treatments,the Pittsburgh sleep quality index(PSQI)was used to quantitatively score the sleep quality of the patients before and after treatments,the occurrences of adverse reactions dur-ing the course of treatments were observed in both groups.Results After treatment,the IRLS scores in two groups sig-nificant decreased than those before treatment(all P＜0.01),and the score in observation group significant decreased than that in control group(all P＜0.01).The total effective rate of observation group was significant higher than that of the control group(P＜0.05).After treatment,the scores of HAMA-14,HAMD-24 and PSQI in two groups significant decreased than those before treatment(all P＜0.05),and the scores in observation group significant decreased than those in control group(all P＜0.05).No serious adverse events were occurred in two groups.Conclusion The combination of Gabapentin and Eszopiclone can effectively alleviate symptoms of RLS,improve anxiety and depression,improve sleep quality of MHD patients,and this treatment approach issafe.