A Real World Research on the Effect of Chanfu Navel Paste on Opioid-induced Constipation

MENG Xianze; REN Hongxian; QIN Xiuju; FENG Yinglu

doi:10.13730/j.issn.2097-2148.2024.10.008

Abstract：Objective To investigate the therapeutic effect of Chanfu navel paste on opioid-induced constipation(OIC)in the real world.Methods 60 patients with OIC admitted to the author's hospital from January 2020 to December 2022 were randomly divided into treatment group(n=30)and control group(n=30)by random number table method.The control group maintained the existing treatment and used lactulose oral solution(30 ml per time,once a day)for defe-cation;on the basis of the treatment of the control group,the treatment group was applied Chanfu navel paste to Shenq-ue,and both groups were treated for 7 days.The changes of bowel function index(BFI)scale and traditional Chinese Medicine(TCM)Syndrome Scale for Gastrointestinal Diseases were compared between the two groups before treatment and at the end of treatment,the adverse reactions during the treatment were also collected.Follow-up was performed 7 days after the end of treatment,and relevant indicators were re-observed to determine the lasting effect after discontinua-tion.Results After 7 days of treatment,the defecation difficulty feeling of endless defecation and the overall evaluation score of constipation in the treatment group were lower than those in the control group(all P＜0.05),and the total TCM syndrome score in the treatment group was lower than that in the control group(P＜0.05).According to BFI symptom score,the total effective rate of the treatment group was 46.67％higher than 3.33％of the control group(P＜0.05)af-ter 7 days of treatment.No significant treatment-related adverse reactions were observed in both groups.After 7 days of follow-up,the overall evaluation of constipation and the total score of TCM syndromes of gastrointes tinal diseases in the treatment group were still better than those in the control group(P＜0.05).Conclusion Chanfu navel paste can improve the symptoms of patients with OIC,and has achieved good therapeutic effect in real world research,which is worthy of further research and popularization.