Value of Serum UⅡ and SCUBE1 in Predicting Cardiovascular Event Outcomes in Obstructive Sleep Apnea-hypopnea Syn-drome Patients

NI Minne; LV Huiying; CHI Bo; LI Yanping

doi:10.13730/j.issn.2097-2148.2024.03.005

Abstract：Objective To investigate the value of serum urotensin Ⅱ(U Ⅱ)and signal peptide,CUB domain and EGF like domain containing 1(SCUBE1)in predicting the occurrence of major adverse cardiovascular events(MACE)in obstructive sleep apnea-hypopnea syndrome(OSAHS)patients.Methods A total of 106 OSAHS patients(OSAHS group)who were diagnosed and treated in author's hospital from February 2019 to February 2022 and 60 healthy people(control group)who underwent physical examination during the same period were selected as the research objects.The patients were divided into mild group(n=42),moderate group(n=36)and severe group(n=28)according to apnea hy-popnea index(AHI)and lowest oxygen saturation(LSaO2)at night.According to whether MACE occured within 1 year follow up,the patients were divided into MACE group(n=32)and non-MACE group(n=74).The levels of serum UⅡand SCUBE1 were detected by enzyme linked immunosorbent assay(ELISA).The predictive value of serum UⅡ and SCUBE1 levels for MACE in OSAHS patients were analyzed by Logistic regression analysis and receiver operating charac-teristic(ROC)curve.Results The levels of serum UⅡ and SCUBE1 in OSAHS group were significantly higher than those in control group,and the difference between the two groups was statistically significant(all P＜0.001).The levels of serum U Ⅱ and SCUBE1 of OSAHS patientes in the mild,moderate and severe groups increased successively,and the difference between the two groups was statistical-ly significant(all P＜0.05).The disease course of OS-AHS,AHI,serum UⅡ level and SCUBE1 level of OSAHS patients in MACE group were significantly higher than those in the non-MACE group,and LSaO2 level was lower than that in the non-MACE group,and the difference between the two groups was statistically significant(all P＜0.05).AHI,serum UⅡ and serum SCUBE1 were identified as independ-ent risk factors for the occurrence of MACE in OSAHS patients,while LSaO2 was found to be the protective factor.The area under the curve(AUC)of serum UⅡ,SCUBE1 and combination of the two for predicting the occurrence of MACE in OSAHS patients was 0.846(95％CI:0.801-0.894),0.812(95％CI:0.770-0.839)and 0.904(95％CI:0.860-0.943)respectively.The predictive efficacy of combined detection of the two was higher than that of serum UⅡ and SCUBE1 alone.Conclusion The levels of serum UⅡ and SCUBE1 are increased in OSAHS patients,which are related to the severity of OSAHS,and they are both involved in the progression of OSAHS.The combined detection of serum UⅡand SCUBE1 has a high predictive value for the occurrence of MACE in OSAHS patients,and it is a new serum marker for evaluating the prognosis of MACE.