Relationship Between Serum CXCL8,CXCL12 and Clinical Outcome of Nitric Oxide Inhalation Therapy in Persistent Pulmo-nary Hypertension Neonates of the Newborn
YAN Xiaoyan
SI Xin
QUAN Yanhua
JIAO Dongju
ZHAI Shufen
Abstract：Objective To investigate the relationship of clinical outcome between serum C-X-C motif chemokine lig-and 8(CXCL8),CXCL12 and nitric oxide inhalation therapy in persistent pulmonary hypertension of newborn(PPHN).Methods A total of 135 PPHN children who were treated with nitric oxide inhalation in author's hospital from August 2021 to May 2023 were selected as study subjects.The children were divided into death group(n=32)and survival group(n=103)according to the clinical outcome at discharge.The levels of serum CXCL8 and CXCL12 in PPHN children were compared between two groups.The influencing factors of clinical outcomes in PPHN children treated with nitric oxide in-halation were analyzed by univariate and multivariate Logistic regression models.The predictive value of serum CXCL8 and CXCL12 on the clinical outcome of PPHN children treated with nitric oxide inhalation were analyzed by receiver oper-ating characteristic(ROC)curve.Results The levels of serum CXCL8 and CXCL12 in PPHN children in death group were significantly higher than those in survival group(all P＜0.05).Multivariate Logsitic regression analysis showed that,elevated serum CXCL8 level,elevated serum CXCL12 level,premature delivery,Apgar score 0-3 at birth and the complications were risk factors for death in PPHN children receiving nitric oxide inhalation therapy;pulmonary surfactant application and early response to inhaled nitric oxide were protective factors(P＜0.05).The results of ROC curve analy-sis showed that,the area under the curve(AUC)of combined detection of serum CXCL8 combined CXCL12 for predic-ting the death of PPHN children receiving nitric oxide inhalation therapy was 0.828,which was greater than that of serum CXCL8 and CXCL12 alone(AUC were 0.762 and 0.714 respectively).Conclusion The increase of serum CXCL8 and CXCL12 levels in PPHN children are related to the poor clinical outcome of nitric oxide treatment,and the increase of the two indicators are risk factors for the death of PPHN children.The combined detection of CXCL8 and CXCL12 has a high predictive value for the death of PPHN children treated with nitric oxide.
Keywords：Persistent pulmonary hypertension of newbornC-X-C motif chemokine ligand 8C-X-C motif chemo-kine ligand 12Nitric oxide inhalation therapyClinical outcome
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 26-30 )