Effects of Probucol Against Renal Ischemia-reperfusion Injury in Rats
YANG Cheng
WU Jiang
REN Xingfeng
Abstract：Objective To investigate the effects of probucol on renal function and renal pathological changes in rats with ischemia-reperfusion (IR) injury.Methods Thirty male SD rats were randomly divided into sham operation group (S group),ischemia reperfusion group (IR group) and probucol treatment group (P + IR group),10 in each group.Rats in S and IR groups were fed with warm water (20 ml/d),and rats in P group were intragastric administration with probucol [250 mg/(kg· d)].After 1 week,rats model of renal ischemia and reperfusion were prepared,and the levels of 24-hour urinary protein,urine β-N-acetylglucosaminidase (NAG),blood urea nitrogen (BUN),serum creatinine (Scr),serum,superoxide dismutase (SOD) and malondialdehyde (MDA) of all rats were measured.The pathological changes of the kidneys were observed,and kidney indexs were calculated.Results Compared with the S group,the levels of 24-hour urinary protein,NAG,BUN,Scr and MDA in IR and P + IR groups all increased (P＜0.05),and the levels of SOD in serum and renal tissues were significantly decreased (P＜0.05).The levels of 24-hour urinary protein,NAG,BUN,Scr and MDA in P + IR group were significantly lower than those in IR group,and SOD levels in serum and renal tissues in P+ IR group increased,meanwhile,MDA levels were significantly decreased (P＜0.05).The pathological damage of kidney tissues was reduced,and renal indexs were significantly improved (P＜0.05).Conclusion Probucol can reduce the renal function and pathological injury of renal tissues in IR injury rats,and play a role in renal protection.
Keywords：ProbucolIschemia-reperfusionKidneyOxidative stress
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 73-76,100 )