Effects of Nicorandil on Inflammatory Response and Myocardial Injury in Acute ST-segment Elevated Myocardial Infarction Patients Before PCI
XU Jiabin
WANG Libo
CHEN Weida
Abstract：Objective To observe the effects of nicorandil on inflammatory response and myocardial injury in acute ST-segment elevated myocardial infarction (STEMI) patients before percutaneous coronary intervention (PCI).Methods One hundred STEMI patients underwent PCI were divided into the routine group (48 cases) and the nicorandil group (52 cases) by random number table.All patients were given conventional treatment for acute myocardial infarction,while the nicorandil group was given an additional 10mg nicorandil 30 min before PCI.The neutrophils-to-lymphocyte ratio (NLR),levels of high-sensitivity C-reactive protein (hs-CRP),cardiac troponin I (cTnI) and creatine kinase MB (CK-MB) were compared between two groups before PCI at 12-and 24-hour postoperative period.The correlation analysis of NLR,hs-CRP,cTnI and CK-MB at 24 hours after PCI was performed.Results The levels of NLR,hs-CRP,cTnI and CK-MB in the nicorandil group were lower than those in the routine group at 12-and 24-hour postoperatively.There were signifantly differences in above indexes except NLR at 12 hours after PCI (P＜0.05).NLR in the first 24 hours after PCI was positively correlated to the levels of hs-CRP,cTNI and CK-MB (r =0.955,0.948,0.949,P＜0.001).The hs-CRP level at 24 hours after PCI was positively correlated to the levels of cTnI and CK-MB (r =0.941,0.944,P＜0.001).Conclusion STEMI patients take nicorandil by orally before PCI can effectively inhibit the inflammatory respone,and thus reduce myocardial injury.
Keywords：Acute ST-segment elevated myocardial infarctionPercutaneous coronary interventionNicorandilInflammatory responseMyocardial injury
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 8-11 )