Intervention Effects of Ginkgolide B on Anxiety Behaviors of Rats Induced by Acute Hypoxia
WANG Li
SHI Qinghai
LIU Liming
RAN Jihua
LIU Zhengxiang
YANG Qi
DENG Mengyun
HU Huiting
FU Jianfeng
Abstract：Objective To investigate the intervention effects of Ginkgolide B (GB) on anxiety behaviors of SD rats induced by acute hypoxia.Methods Thirty-six SPF grade SD rats were separated into there groups:control group,acute hypoxia group and GB group,each 12 rats.Based on the plateau artificial laboratory module platform,the rats were fed on plains normoxic condition as the plain control group.The plateau hypoxia model was established in plateau hypoxia group and GB intervention group by exposing to 6000 metres altitude for 6 days,and GB group was previously given GB (12 mg/kg·d) lasting 4 days by gastric perfusion.The open filed test (OFT) and elevated plus maze (EPM) were applied to evaluate anxiety behaviors of acute hypoxia rats.Results The time of entering the central region,frequency and total exercise distance of plain control group in OFT were significantly higher than those of plateau hypoxia group (P＜0.05).The percentage of open-arms time and frequency in EPM test were also significantly higher than these of plateau hypoxia group (P＜0.05).The various indexes of GB group in both OFT and EPM tests were obviously higher than these of acute hypoxia group (P＜0.05).Conclusion Pre-given GB can effectively alleviate the high altitude anoxia-induced anxiety-like behaviors in rats.
Keywords：Ginkgolide BAcute hypoxiaAnxietyOpen field textElevated plus maze
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )