Transcuataneous Electrical Nerve Stimulation Alleviates Chemotherapy-induced Nausea and Vomiting in Gastric Cancer Patients
LI Hui-yan
YANG Qi
XU Hao
ZHANG Rong
LI Ji
ZHANG Chao
Abstract：Objective To observe the influence of transcuataneous electrical nerve stimulation (TENS) for chemotherapy-induced nausea and vomiting (CINV) in patients with gastric cancer,and explore the role of vomiting-associated bioactive substance 5-hydroxytryptamine (5-HT) in the process.Methods In this investigation,94 patients with gastric cancer were assigned into three groups by random number table,including dolasetron group (DOLA,n =31),TENS + DOLA group (n =32) and TENS group (n =31).The patients of DOLA and TENS + DOLA groups were administered with 100 mg dolasetron intravenously per day.For the TENS + DOLA and TENS groups,the five acupoints of bilateral Neiguan and Zusanli,Zhongwan and such were stimulated for 30 min/d,the electricity frequency was 2/100 Hz of dilatational wave,and the current intensity ranged from 8-10 mA.The TENS stimulation started at the day of chemotherapy,and ended at the sixth day after the chemotherapy.Results The CINV effective rate in DOLA group was 61.3％,the effective rate of CINV in TENS+ DOLA group was 81.3％,and 77.4％ in TENS group.No difference were found in three groups (P＞0.05).The plasmic 5-HT concentration reduced in both DOLA + TENS group and TENS group in 2-6 days after the chemotherapy (P＜0.001).Conclusion TENS can alleviate the incidence of CINV in patients with gastric cancer,and the potential mechanism may associate with the reduction of plasmic 5-HT level.
Keywords：Transcuataneous electrical nerve stimulationGastric cancerChemotherapyNausea and vomiting5-hydroxytryptamine
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 803-806 )