Effects of Levetiracetam on Mental and Psychological Status of Adolescent with Partial Epileptic Seizures
CAI Ya-min
WEN Wen
JU Lin-li
YE Mao-lin
Abstract：Objective To investigate the effects of levtiracetam on mental and psychological status of adolescent with partial epileptic seizures.Methods Seventy-two adolescents with partial epileptic seizures from department of neurology in author's hospital were collected as study objects,and then randomly divided into observation group (n =36) and control group (n =36).The adolescents in the control group were treated with oxcarbazepine,and the adolescents in the observation group were used with oxcarbazepine plus levetiracetam.After 16 weeks treatment,the average weekly frequencies of partial epileptic seizures were analyzed.The scores of Epworth sleepiness scale (ESS) scores,Hamilton anxiety scale (HAMA) scores,Hamilton depression scale (HAMD) scores and adverse reactions were compared between two groups.Results The average weekly frequencies of partial epileptic seizures in the observation group were significantly lower than these in the control group (P＜0.01),and ESS,HAMA and HAMD scores in the observation group were obviously higher than those in the control group (P＜0.01).There was no significant difference in adverse reactions between two groups (P＞0.05).Conclusion Levetiracetam helps to reduce the frequency of partial epileptic seizure in adolescents,but it also causes mental and psychological problems such as sleepiness,anxiety and depression.The clinical use of levetiracetam should weigh the pros and cons.
Keywords：LevetiracetamPartial epileptic seizuresMental statesPsychological states
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 685-687,714 )