Change Rules of Neuron-specific Enolase, D-dimer and Homocysteine in Patients with Acute Ischemic Stroke

ZHOU Jing-fen; WU Ting-yu

doi:10.13730/j.issn.1009-2595.2017.10.005

Abstract：Objective To analyze the changes of neuron-specific enolase (NSE),D-dimer (DD) and homocysteine (Hcy) in patients with acute ischemic stroke,and provide the references for clinical diagnosis in the furture.Methods Eighty-nine patients with acute ischemic stroke from January 2014 to December 2016 were enrolled in this study as observation group.Ninety health people in the same period were selected as control group.The NSE,DD and Hcy levels of patients in two groups were detected,and the patients in observation group were tested at 2nd,5th and 10th day after onset respectively.Results in observation group were compared with those in control group.The patients of different sex in observation group contrasted the serum NSE,D-D and Hcy levels at 2nd day.The patients in observation group were divided into three subgroups of large,medium and small groups,according to the results of brain magnetic resonance imaging (MRI) after admission.The results of various indexes in three groups were compared.Results The serum NSE,DD and Hcy levels in the observation group were significantly higher than those in the control group at the 2nd,5th and 10th day (P＜0.05).The serum NSE and DD levels in the observation group increased from the 2nd day,peaked at 5th day,and decreased from 10th day.There were significantly differences in D-D and Hcy levels between male and female patients (P＜0.05),but no difference was found in serum NSE levels (P＞0.05).The NSE,DD and Hcy results of three subgroups at the 2nd day showed that the more the infarct size,the higher the NSE and DD levels,but Hcy levels had no obvious change.Conclsion The infarct sizes in patients with acute ischemic stroke are more,the higher the NSE and DD levels.It can be used as a quantitative basis for neuronal injury in clinical diagnosis.Hcy can be used as an auxiliary index.