Efficacies and Effects on IL-4, IL-37 and INF-γ Levels of NB-UVB Combined with Mucopolysaccharide Polysulfate Cream in Treatment of Psoriasis
NING Xu
Abstract：Objective To investigate the clinical value of narrow-band ultraviolet B (NB-UVB) combined with mucopolysaccharide polysulfate cream in treatment of psoriasis.Methods Sixty-six patients with psoriasis in author's hospital from February 2013 to June 2016 were divided into control group and observation group by random number table with 33 cases each.Two groups were treated with NB-UVB,but the observation group was additionally treated with mucopolysaccharide polysulfate cream.The psoriasis area and severity index (PASI) scores were performed,and the therapeutic effects were compared between two groups.Changes of serum interleukin 4 (IL-4),interleukin 37 (IL-37),interferon γ (IFN-γ) and tumor necrosis factor α (TNF-α) levels in two groups were detected before and after treatment.The adverse reactions in two groups were observed.Results ①After treatment,the PASI scores,IL-37,IFN-γ and TNF-α levels were all decreased in two groups (P＜0.05),and above indexes of the observation group were lower than those of the control group (P＜0.05).②The total effective rate of observation group was significantly higher than that of control group (P＜ 0.05).③There was no significantly difference between two groups in the total incidence rate of adverse reactions (P＞ 0.05).Conclusion NB-UVB combined with mucopolysaccharide polysulfate cream is effective in the treatment of psoriasis,and it can reduce IL-37,IFN-γ and TNF-α levels and relieve the symptoms of skin lesions with high safety.
Keywords：PsoriasisNarrow-band ultraviolet BMucopolysaccharide polysulfate creamSkin lesions
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 657-660 )