Effect of Bi-level Positive Airway Pressure Ventilator and Budesonide for COPD Patients Combined with Type Ⅱ Respiratory Failure
YANG Yu
XU Xi-lin
TANG Zhong-zhi
CHEN Zhen-zhen
Abstract：Objective To study clinical influence of combination therapy of bi-level positive airway pressure (BiPAP) ventilation and inhaling budesonide for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients with type Ⅱ respiratory failure.Methods A total of 90 AECOPD patients with type Ⅱ respiratory failure were randomly divided into 3 groups.Routine group(n =30):patients were treated with basic treatment,BiPAP group (n =30):patients were treated with basic treatment and BiPAP ventilation.BiPAP + budesonide group(n =30):patients were treated with combination therapy of BiPAP ventilation and inhaling budesonide.Results Compared with routine group,pH,arterial partial pressure of oxygen (PaO2),arterial partial pressure of carbon dioxide (PaCO2),respiratory rate(RR) and heart rate (HR) at 12h,24h,48h and 72h of BiPAP + budesonide group and BiPAP group had obviously improved(P＜0.05).There were significantly different between BiPAP group and BiPAP + budesonide group of pH and HR (12h,24h and 48h after treatment),PaO2 (12h and 24h after treatment),PaCO2 (12h after treatment) (P＜0.05).The hospital stays were shortest in BiPAP + budesonide group(P＜0.01),C-reactive protein (CPR) and modified British medical research council (mMRC) scores were better than other groups(P＜0.05).Conclusion The effect of combination therapy of BiPAP ventilation and inhaling budesonide for the AECOPD patients with type Ⅱ respiratory failure is better than traditional treatment or BiPAP ventilation singly.The technique is worthy to promotion.
Keywords：Acute exacerbation of chronic obstructive pulmonary diseasebi-level positive airway pressureBudesonide
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 604-608 )