Clinical Analysis of 8 Multiple Myeloma Patients Complicated with Spinal Infiltration
ZHANG Xin-hua
RAN Qi-jie
XU Biao
SONG Sen-hua
LI Jing-yuan
ZHOU Min
LIU Long-long
Abstract：Objective To study the clinical features,diagnosis and treatment of multiple myeloma (MM) complicated with spinal infiltration.Methods A total of 8 MM patients complicated with spinal infiltration were enrolled in this study from November 2011 to October 2016 in author's hospital.The clinical records,magnetic resonance imaging (MRI) or computed tomography (CT) scans,different treatments and efficacies of the patients were analyzed retrospectively.Results All the 8 patients had thoracic spinal cord involvement.It was within only a few hours to 3 days that symptoms of backache and numbness of lower limbs progressed to paraplegia for 6 patients.The spinal infiltration by MM was confirmed by MRI,CT and histopathological analysis.Of the 7 patients who received tumor therapy,3 underwent surgery and followed by chemotherapy,consisted of bortezomib-containing regimens or other regimens.The lower limb muscle strength recovered from 0 degree to 3 degree for 1 patient,and unimproved for the other 2 patients.Two cases received chemotherapy only,whose muscle strength not improved at all.Two cases who received radiotherapy achieved complete recovery or near complete recovery of the muscle strength.No serious adverse responses were observed of all the 7 patients.Conclusion The thoracic spinal cord is the common site of spinal infiltration by MM,and MRI is the best method of diagnosis.The treatment must be obtained as early as possible,and radiotherapy is the best choice for improvement of nervous function.
Keywords：Multiple myelomaSpinal cordInfiltrationTumor therapy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 593-596 )