Effects of Short-term Using of Cinacalcet on Hematopoietic Fibroblast Growth Factor 23 and Blood Osteoprotegerin in Hemodialysis Patients with Secondary Hyperparathyroidism
JIN Zheng-xi
ZHANG Jing
WANG Hong-mei
CHEN Qiang
Abstract：Objective To investigate the influence of short-term using of cinacalcet hydrochloride on high serum phosphorus, blood calcium, intact parathyroid hormone (iPTH),blood fibroblast growth factor-23 (FGF-23) and blood osteoprotegerin (OPG) of chronic hemodialysis patients complicated with secondary hyperparathyroidism (SHPT).Methods Twenty chronic hemodialysis patients complicated with SHPT (blood calcium>2.75 mmol/L, calcium-phosphorus product>4.52 mmol2/L2) in hemodialysis center of authors,hospital were analyzed.The serum phosphorus, blood calcium, iPTH, FGF-23, blood OPG were observed after 4 weeks treatment with cinacalcet.Results After 4 weeks treatment with cinacalcet, the levels of serum phosphorus, blood calcium, iPTH, FGF-23, blood OPG were lower than those before the cinacalcet treatment of all 20 patients.The hemoglobin,albumin had no changes before and after the treatment of cinacalcet.Conclusion Short-term using of cinacalcet can effectively correct serum phosphorus, blood calcium, iPTH, FGF-23, blood OPG for chronic renal failure patients complicated with SHPT.Cinacalcet can cause nausea, vomiting, low calcium, other adverse reactions, and it is appropriate to short-term use.
Keywords：CinacalcetChronic renal failureSecondary hyperparathyroidismSerum fibroblast growth factor-23Serum osteoprotegerin
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 372-375 )