Expression and Clinical Significance of Tumor Endothelial Marker 8 in Non-small Cell Lung Cancer
REN Yong
HE Wei
CHEN Xin-wei
LIANG Li-wei
FENG Jun-ming
Abstract：Objective To investigate the expression and clinical significance of tumor endothelial marker 8 (TEM8) protein in non-small cell lung cancer (NSCLC) and adjacent non-cancerous normal lung tissues.Methods TEM8 expressions were evaluated in NSCLC tissues (n=110) and adjacent normal lung tissues (n=30) by immunohistochemistry.The correlation between TEM8 expressions and NSCLC clinicopathological parameters, and survival rates were analyzed by statistical methods.Results The positive expression rate of TEM8 was significantly higher in NSCLC tissues (52.72%) than that in adjacent normal lung tissues (6.67%) (P<0.01).The expression of TEM8 in NSCLC was correlated with differentiation degree, TNM stage and lymph node metastasis (P<0.05).Kaplan-Meier survival analysis suggested that the positive expression of TEM8 was negatively correlated with the overall survival rate (P<0.05).Conclusion High level of TEM8 expression is significantly correlated with NSCLC progression and poor prognosis, so it can be used as a novel NSCLC biomarker
Keywords：Non-small cell lung cancerTumor endothelial marker 8PrognosisImmunohistochemistry
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 359-362 )