Laryngeal Leiomyosarcoma:A Case Report and Review of Literatures
ZHONG Hai-lin
XIE Ming
TANG Yuan
XING Cheng-liang
WANG Wei-zhong
ZHONG Wen
FU Qian
Abstract：Objective To investigate the clinical features,diagnostic and therapeutic methods of laryngeal leiomyosarcoma (LMS).Methods The one laryngeal LMS cases and relevant literatures were reviewed.Results The fiber laryngoscopy showed a cauliflower-like tumor without fester in the glottis which showed a fissured shape.The re-examination of fiber laryngoscopy showed a gray-white pseudomembrane on the surface of the tumor which proliferated and extended all of the glottic area, and the subglottic area could not be detected.Computed tomography (CT) showed a nodular middle-density mass in the epiglottis,two-sided vocal cord abducting paralysis and anterior commissure.Enhanced scan showed homogeneous contrast enhancement in the arterial phase,with unclear boundary.Hematoxylin-eosin stains demonstrated that tumor tissues were composed of spindle cells.The cells had wide and abundant cytoplasm with eosinophilic red dye.And many cells were obviously atypia and mitotic.Immunohistochemistry detection showed positive were vimentin,caldesmon,smooth muscle actin, and desmin,at the same time,negative were myoglobin,tyrosine phosphokinase receptor,melanin specific antibody,cytokeratin,and S-100.Conclusion Laryngeal leiomyosarcoma is an extremely rare solid tumor,a poor prognosis,and its diagnose depends on histopathology and immunohistochemistry detections.
Keywords：Laryngeal leiomyosarcomaDiagnosisTreatment
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 321-323 )