Clinical Observation of Cyberknife Therapy Combined with Hyperthermia and Tegafur for Treatment of Recurrent and Metastatic Hepatocellular Carcinoma
YANG Ying
KANG Jing-bo
ZHAO Xiang-fei
ZHANG Bao-he
XU Hong-tao
Abstract：Objective To evaluate the efficacy and toxicity of cyberknife therapy combined hyperthermia with tegafur for treatment of recurrent and metastatic hepatocellular carcinoma.Methods From January 2013 to January 2015,84 patients with recurrent and metastatic hepatocellular carcinoma, in accordance with different therapeutic methods, were divided into control group and observation group.Forty-three patients in control group were treated with cyberknife therapy and hyperthermia, while forty-one patients in observation group used cyberknife combined hyperthermia with tegafur.Results Total efficacy rate after a three-month treatment was 79.76%.The efficiency rate, 1-and 2-year local control rate in observation group were 87.80%, 60.00%, 35.00%,and all higher than 72.09%, 46.34% and 24.39% in control group.No significant differences were found between two groups (P>0.05).One-and three-year survival rate in control group were separately 46.34% and 7.32% with the median survival of 10.5 months.One-and three-year survival rate in observation group were separately 65.00% and 17.5% with the median survival of 13.5 months(P<0.05).The adverse reaction rates in two groups were not significantly different (P>0.05).Conclusion The combination of cyberknife therapy with hyperthermia and tegafur is a safe and useful method in treatment of recurrent and metastatic hepatocellular carcinoma.
Keywords：Hepatocellular carcinomaCyberknife therapyHyperthermiaTegafur
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 236-239 )