Influence of Fenofibrate on Level of Serum Lipoprotein Associated Phospholipase A2 and Treatment of Diabetic Retinopathy
JU Hai-bing
ZHU Hong-yun
ZHANG Fu-xian
WANG Shuang
SONG Jie
CUI Tao
LI Li-feng
RUAN Zhao-juan
HE Hui-mei
Abstract：Objective To observe effect of fenofibrate on level of lipoprotein-associated phospholipase A2 (Lp-PLA2),visual function and retinal morphology in diabetic retinopathy (DR) patients,and explore the application value of fenofibrate in prevention and treatment of DR.Methods A total of 67 patients (134 eyes) with non-proliferative diabetic retinopathy (NPDR group) and 42 cases (84 eyes) with proliferative diabetic retinopathy (PDR group) were randomly divided into two subgroups: the treatment group and the control group.The cases of control group and treatment group were given routine drugs and routine drugs plus fenofibrate treatment for 12 weeks respectively.The vision,retinal morphology and changes in levels of serum Lp-PLA2 of two groups were compared before and after treatment.Results After 12 weeks of fenofibrate treatment,the levels of Lp-PLA2 (P<0.01) and vascular endothelial growth factor (VEGF) (P<0.05) in NPDR patients were decreased,the levels of Lp-PLA2 (P<0.01) and VEGF (P<0.05) in PDR patients were decreased.The effective rates of visual acuity and fundus lesions were improved in NPDR patients more than those in control group (P<0.05).Conclusion Fenofibrate treatment can significantly reduce levels of serum Lp-PLA2 and VEGF in patients with DR.Fenofibrate treatment of NPDR patients can significantly improve the visual acuity and fundus lesions,delay the progression of retinopathy.
Keywords：Diabetic retinopathyFenofibrateLipoprotein-associated phospholipase A2Vascular endothelial growth factor
Publication Date：2017-01-01
Pages：4( 170-173 )