Impact Analysis of Ovarian Function and Glucose Metabolism by Diane-35 Combined with Metformin Treatment in Polycystic Ovary Syndrome Patients with Abnormal Glucose Metabolism
TANG Xiao-you
WU Shao-zheng
LIAO Yong
FENG Hai-po
YAN Hong-liang
LIU Shu-qi
Abstract：Objective To analyze impact of ovarian function and glucose metabolism by Diane-35 (containing approximately 20 mg of cyproterone acetate and 35μg of ethinylestradiol) combined with metformin treatment in polycystic ovary syndrome patients with abnormal glucose metabolism.Methods A total of 100 abnormal glucose metabolism patients with polycystic ovary syndrome from June 2013 to January 2015 inauthors hospital were divided into control group and experimental group by drawing lots(n =50).The control group was treated with Diane-35,and experimental group was treated with metformin on the basis of control group'treatment.The hemorrhagic hormone levels,indexes of sugar metabolism,body mass index (BMI) and homeostasis model assessment-insulin resistance (HOMA-IR),ovarian volume changes by ultrasonic measurement,and menses return,ovulation and pregnancy rate after treatment were compared between two groups.Results It was no differences in hemorrhagic hormone levels,indexes of sugar metabolism,ovarian volume,BMI,waist-to-hip Ratio (WHR) of two groups before treatment (P＞0.05).The follicle stimulating hormone (FSH),luteinizing hormone (LH),estradiol (E2),testosterone (T),fasting blood glucose (FBG),fasting blood-insulin (FINS),HOMA-IR,ovarian volume,BMI and WHR of experimental group after treatment was lower than control group,respectively (P＜0.05).The menses return,ovulation and pregnancy rate of experimental group was higher than control group (P＜0.05).Conclusion Diane-35 combining with metformin treatment creates more effective in glycometabolism of polycystic ovary syndrome patients with abnormal glucose metabolism,improves ovarian function and increases pregnancy rate.
Keywords：Abnormal glucose metabolismPolycystic ovary syndromeDiane-35MetforminOvarian function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 80-83,96 )