A Meta-analysis on the Association Between rs10046 Polymorphism of CYP19A1 and Susceptibility of Breast Cancer
YOU Lu-kuan
CHEN Wen-fu
CHEN Chu-peng
LU Wei-zhong
Abstract：Objective To investigate the association between polymorphism of CYP19A1 gene(rs10046) and susceptibility of breast cancer through a Meta-analysis.Methods The case-control studies from PubMed,Embase,CNKI,VIP,and Wanfang for the association between CYP19A1 gene (rs10046) polymorphisms and breast cancer were searched.The pooled OR with 95 ％CI were calculated to assess the association strength using Meta methods by Stata 11.1,and heterogeneity and publication bias were evaluated.Results Fifteen case-control studies with 9241 cases and 12 681 controls were analysed.There was not any obvious difference between CYP19A1 gene (rs10046) polymorphism and the susceptibility of breast cancer(T vs.C:OR =0.929,95％CI:0.778-1.110,P=0.420;TT vs.CC:OR =0.902,95％CI:0.671-1.211,P =0.492;TC vs.CC:OR=0.996,95％CI:0.929-1.067,P =0.909;TT + TC vs.CC:OR=0.934,95％CI:0.784-1.112,P =0.442;TT vs.CC + TC:OR =0.920,95 ％ CI:0.699-1.209,P =0.548).Similar results were emerged in the stratified analyses of the ethnicity(Caucasian and Ascian),control group source(hospital-based and populationbased)and literature quality(high-score and low-score).Conclusion There is no significant correlation between CYP19A1 gene(rs10046) polymorphism and the susceptibility of breast cancer.
Keywords：CYP19A1PolymorphismBreast cancerMeta-analysis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)