Expression and Clinical Significance of ANTXR1 in Esophageal Squamous Cell Carcinoma Tissue
REN Yong
HE Wei
QI Man-li
CHEN Xin-wei
LIANG Li-wei
FENG Jun-ming
Abstract：Objective To investigate the expression and significance of ANTXR1 protein in esophageal squamous cell carcinoma (ESCC) tissues.Methods The expression of ANTXR1 mRNA and protein in ESCC tissues and adjacent normal tissues were detected by real-time polymerase chain reaction (real-time PCR) and immunohistochemistry.Results In 10 pairs of the fresh ESCC tissues,the mRNA level of expression of ANTXR1 was higher than that of the adjacent normal tissues (P＜0.01).The positive rate of expression of ANTXR1 protein in 172 cases of the ESCC sections was significantly higher than that in the adjacent normal sections (P＜0.01).The expression of ANTXR1 protein was significantly correlated with histological differentiation,lymph node metastasis,neoplasm staging and clinic prognosis (P＜ 0.05),but not with age,gender,infiltration degree and size of tumor (P＞0.05).Conclusion The high expression of ANTXR1 protein in ESCC tissues and ANTXR1 expression is related to the patients' prognosis.ANTXR1 may be a novel oncogene relating to the tumorigenesis and tumor progression of ESCC,and could supply new ideas for the prognosis and treatment of
Keywords：Anthrax toxin receptor 1Esophageal squamous cell carcinomaClinical significance
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)