Experimental Research of Qi-Xiong Compound Particles in Treating Rheumatoid Arthritis
WANG Jun-wei
CHEN Li-feng
WANG Hua-song
CHEN Fang
Abstract：Objective To observe the therapeutic action of Qi-Xiong compand particles on rheumatoid arthritis (RA).Methods A total of 28 New Zealand rabbits were randomly divided into normal group,model group,Tripterysium Glycosides (TPT) group,and Qi-Xiong compound particles (TCM) group.The adjuvant arthritis (AA) animal model was induced by complete freund's adjuvant.Four weeks later after modeling,the normal group and model group were treated with normal saline (5 ml/kg),TPT group treated with TPT (5.72 mg/kg),TCM group treated with Qi-Xiong compound particles (5 g/kg) by gastric perfusion once a day for 3 weeks.The weight and the perimeters of the hind toe of AA rabbits were measured before and after modeling and three weeks after therapy.The changes of the soft tissue and bone were assessed by X-rays.The levels of interleukin 17 (IL-17) and interleukin 23 (IL-23) in the serum of AA rabbits were detected by enzyme-linked immunosorbent assay (ELISA).Results After three weeks,joint swelling of therapy groups decreased compared with the model group (P＜0.05),and of TCM group decreased more (P＜0.01).Compared with the normal group,the soft tissue edema of model group was more serious,joint space was narrower or even obscured,and the articular surface was not smooth.Compared with the model group,the lesion of therapy groups showed mild symptoms,and the level of IL-17,IL-23 decreased significantly (P＜0.01).Compared with TPT group,the level of IL-17,IL-23 in TCM group reduced significantly (P＜0.05).Conclusion Qi-Xiong compound particles have obvious suppressive function on AA rabbits and better anti-inflammation and swelling relief effect in treating rheumatoid arthritis than TPT.
Keywords：Qi-Xiong compand particlesRheumatoid arthritisRabbit
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)