Exploring Thromboembolic Risk in Patients with Rheumatic Heart Disease by Transesophangeal Echocardiography and Detection of Fibrillolytic Activity in Blood Plasm
Li Qin
Zhang Duanwei
Abstract：Objectives To explore the prethrombotic state (PTS) and mechanism of thrombosis in the patients with rheumatic heart disease. Methods Two hundred and three patients with rheumatic heart disease were examined by transesophageal echocardiography (TEE). The von Willebrand factor antigen (vWF:Ag)、 activated platelet marker α granule membrane protein-140 (GMP-140)、fibrinous peptide A (FPA) and fibrinous D-Dimer (D-D) in the plasm were determined by ELISA method in the 15 patients with rheumatic heart disease and atrial fibrillation and in the 15 health adults who served as control. Results The smoke-like echo was found in 90.1% of the patients with rheumatic heart disease and thrombosis in 30.5% of them. The thrombosis in the patients with atrial fibrillation was significantly different from that in the adults with sinus rhythm (P<0.001). The plasm levels of vWF:Ag,GMP-140,FPA and D-D in the patients with rheumatic heart disease were significantly higher than those in the control group (P<0.01). Conclusion There are the PTS, which is the base of thrombosis, the specially abnormal blood coagulation system in the patients with rheumatic heart disease and atrial fibrillation. The left atrial spontaneous echo contrast is a good factor which can predict thromboembolic risk and of a great value clinically.
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Publication Date：2001-04-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 12-14 )