Nursing management for ICANS of CAR T-cell therapy in B cell acute lymphoblastic leukemia
Hui-Yao Yang
Jing-Jing Jin
Qian-Qian Zhang
Yan-Xia Liu
Ying Wang
Zhi-Xin Wang
Jun-Ping Zhang
Wen-Jun Xie
Abstract：Objective: Immune effector cell-associated neurotoxic syndrome (ICANS) is one of the most concerning complications because of its life-threatening trait during chimeric antigen receptor (CAR) T-cell therapy and requires specialized management. We summarized the nursing procedures of CAR T-cell therapy for ICANS to provide some references for the standardized nursing care of ICANS.
Methods: Based on previous experience and literature research, the professional team developed nursing procedures for ICANS for patients receiving CAR T-cell therapy.
Results: The professional team developed step-by-step, sophisticated care procedures before, during, and after ICANS, including active communication and collaboration, knowledge updates, personalized nursing plans, advanced assessments, close monitoring of vital signs and laboratory tests, medication plans, timely and correct drug administration, dietary nursing interventions, safety care, nursing of other complications, follow-up of toxicities, and keeping an eye on the potential side effects.
Conclusions: ICANS is unique, with varying clinical symptoms and rapid progression. Timely and accurate treatment and care of patients is an effective way to manage ICANS. Professional and detailed procedures are required to guide nurses to manage patients' ICANS, so as to improve the safety of patients and the promotion of CAR T-cell therapy.
Keywords：chimeric antigen receptor-T cell therapyimmune effector cell associated neurotoxicity syndromemanagementnursing rolessymptom management
Publication Date：2025-12-30
Online Publishing Date：2026-01-22(First online date of this platform, not the publication date of the document)
Pages：8( 415-422 )