Study on the mechanism of nursing intervention based on environmental enrichment on cognitive function in ischemic stroke rats
Qing Wu
Yang Li
Pei-Pei Du
Yan Chen
Abstract：Objective: Investigating the effects and molecular mechanisms of nursing interventions based on environmental enrichment on cognitive function in ischemic stroke rats.
Methods: A total of 30 Sprague-Dawley (SD) rats belonging to the same batch were randomly divided into 3 groups (n=10) using a random number table: Sham Surgery Control Group (Sham), Ischemia-Reperfusion (I/R) Group, and Ischemia-Reperfusion Group with Environmental Enrichment Intervention (I/R+EEI). The expression levels of brain-derived neurotrophic factor (BDNF) protein in the hippocampus region were measured and compared among different groups.
Results: Compared with the Sham group, the I/R group showed significantly reduced learning and memory abilities, with notably lower BDNF levels (P＜0.05). Compared to the I/R group, the I/R+EEI group exhibited significantly improved learning and memory abilities as well as increased BDNF protein levels (P＜0.05).
Conclusions: Abnormal BDNF protein secretion may be the molecular mechanism of cognitive dysfunction due to hippocampal neuronal damage in ischemia-reperfusion, and modifying this neurotransmitter's secretion can effectively improve cognitive function in ischemia-reperfusion rats.
Keywords：cognitive dysfunctionenvironmental enrichmentischemic strokebrain-derived neurotrophic factor
Publication Date：2025-09-20
Online Publishing Date：2025-10-13(First online date of this platform, not the publication date of the document)
Pages：6( 311-316 )