The Clinical Application Value and Mechanism Research of Nutritional Enhancement Strategies in the Combined Treatment of Locally Advanced and Advanced Gastric Cancer with Oxaliplatin and Tegafur-Uracil
Wang Bo
Yuan Dongdong
Wang Xiaofang
Abstract：Objective:Exploring the clinical application value and mechanism of nutritional enhancement strategies in the combined treatment(SOX regimen)of oxaliplatin and tegafur-uracil for locally advanced and advanced gastric cancer.Methods:Selecting 80 patients with advanced and terminal gastric cancer admitted to Anyang Cancer Hospital from October 2020 to March 2024 who were randomly divided into nutritional group(n=40)and conventional group(n=40).The conventional group received conventional chemotherapy intervention,and the nutritional group received nutritional fortification strategy intervention on the basis of the conventional group.The general information,nutritional indexes,nutritional status and quality of life in the two groups were compared.Results:After 2 months of intervention,the levels of serum prealbumin(PA),albumin(ALB)and hemoglobin(HB)in the nutritional group were higher than that in the conventional group,the Patient-Generated Subjective Global Assessment(PG-SGA)score of the nutrition group was lower than that of the conventional group,the scores of emotional function,cognitive function,physical function,role function and social function of the nutritional group were higher than that in the conventional group,with statistically significant differences(P＜0.05).Conclusion:The application of nutritional enhancement strategies in the combined treatment of advanced and locally advanced gastric cancer with oxaliplatin and tegafur-gimeracil-oteracil potassium can significantly improve the nutritional status and quality of life of patients.
Keywords：Nutrition fortification strategyOxaliplatinTeggioAdvanced and locally advanced gastric cancer
Publication Date：2026-03-10
Online Publishing Date：2026-04-01(First online date of this platform, not the publication date of the document)
Pages：4( 547-549,553 )