Clinical Value Analysis of Serum Enzymes,HBV-DNA Load and Five Indicators of Hepatitis B in Patients with Chronic HBV Infection

Shen Xueman; Duan Deling; Li Xinyi

doi:10.3969/j.issn.1004-5775.2026.03.017

Abstract：Objective:To investigate the clinical value of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),glutathione reductase(GR),HBV-DNA load and five hepatitis B indicators in patients with chronic hepatitis B virus(HBV)infection.Methods:A total of 167 patients with chronic hepatitis B(CHB)admitted to General Hospital of Southern Theater Command of the People's Liberation Army of China from January 2020 to March 2024 were selected as the research objects,while the control group included 40 healthy patients;leading to 48 patients as the cirrhosis group and 119 non-cirrhosis group.The levels of serum ALT,AST,GR,AST/ALT ratio,HBV-DNA load and hepatitis B five indexes in hepatitis B patients were retrospectively analyzed.Results:Compared with the non-cirrhosis group,the levels of serum ALT,AST,GR,the proportion of high HBV-DNA load(＞1.0×105),and AST/ALT were all higher in the cirrhosis group;non-cirrhotic patients were prone to develop into cirrhotic patients with increasing age,and AST/ALT＞1 was more common in men,the differences were statistically significant(P＜0.05),but there was no significant difference in the positive rate of hepatitis B e antigen(HBeAg)and hepatitis B surface antigen(HBsAg)between the two groups(P＞0.05).There was no significant difference in serum ALT,AST,GR levels and AST/ALT ratio between HBsAg(+)and HBsAg(-)patients(P＞0.05).There were significant differences in serum ALT,AST,and GR levels among patients with different HBV-DNA load(P＜0.05),and with the increase of HBV-DNA load,the levels of ALT,AST and GR showed an upward trend.There was no significant difference in the AST/ALT and positive rate of HBeAg among patients with different HBV-DNA load(P＞0.05).Serum GR,ALT and AST levels of CHB patients were higher than those of the control group,and the rate of HBV in the group was higher in males than in females,the differences were statistically significant(P＜0.05).The receiver operating characteristic(ROC)curves showed that serum GR combined with ALT and AST had high diagnostic efficacy for the detection of CHB and hepatitis B cirrhosis,the differences were statistically significant(P＜0.05).Conclusion:The serum ALT,AST,GR,HBV-DNA load and five indicators of hepatitis B in CHB patients have certain application value in judging chronic hepatitis B cirrhosis,the severity of liver damage in CHB patients and improves the diagnosis level of liver cirrhosis.