The Effects of Different Gynostemma Pentaphyllum Saponin on the Oxidative Stress Levels of CNP Models
Du Xingang
Shen Hao
Zhai Xueru
Abstract：Objective:To investigate the effects of low,medium,and high doses(100 mg/kg,200 mg/kg,300 mg/kg)of saponins from Gynostemma pentaphyllum on oxidative stress levels in a rat model of chronic nonbacterial prostatitis(CNP).Methods:A total of 70 specific pathogen free(SPF)grade SD rats were selected,with 15 rats as the blank group and 55 rats as the model group.Establishing a CNP rat model using carrageenan after one week of modeling,5 rats from each group were euthanized to confirm the modeling results.After successful modeling,the model rats were divided into five groups:model group,Qianlietai capsule group,and low,medium,and high dose groups of Gynostemma pentaphyllum saponins,with 10 rats in each group.After 4 weeks of drug intervention,the differences in prostate index(PI),superoxide dismutase(SOD),malondialdehyde(MDA),and glutathione peroxidase(GSH-Px)content were observed in each group of rats.Results:The PI of the Qianlietai capsule group and the low,medium,and high dose groups of Gynostemma pentaphyllum saponins were significantly reduced compared to the model group,the difference was statistically significant(F=46.586,P＜0.01).Compared with the model group,the levels of SOD and GSH-Px in Qianlietai capsule group and the low,medium,and high dose groups of Gynostemma pentaphyllum saponins were significantly increased,while the levels of MDA were significantly decreased,and the difference was statistically significant(F=219.959,21.406;P＜0.01).Compared with the Qianlietai group,the high-dose group of Gynostemma pentaphyllum saponins showed significantly increased levels of SOD and GSH-Px,and significantly decreased levels of MDA,with statistically significant differences(F=96.252,1.459,2.899;P＜0.01).Conclusion:Low,medium,and high doses of Gynostemma pentaphyllum saponins could significantly reduce prostate index,while medium and high doses could increase SOD and GSH-Px levels,reduce MDA levels,thereby exerting antioxidant effects and delaying disease progression
Keywords：Gynostemma pentaphyllum saponinsChronic nonbacterial prostatitisProstate indexOxidative stress response
Publication Date：2026-02-10
Online Publishing Date：2026-03-16(First online date of this platform, not the publication date of the document)
Pages：3( 259-261 )