Observation on the Efficacy of Compound Furoxone Syrup Combined with Dose Theophylline in Treating Children with Wheezing Bronchopneumonia

Tai Yinfeng; Hu Xiaoxuan; Liang Chengxiang

doi:10.3969/j.issn.1004-5775.2026.01.021

Abstract：Objective:To analyze the efficacy and safety of compound furocin syrup combined with doxepin injection in treating children with wheezing bronchopneumonia.Methods:A retrospective analysis of clinical data from 92 pediatric patients with wheezing bronchopneumonia treated at Xinyang People's Hospital between September 2021 and August 2023.Patients were divided into a combination therapy group(treated with theophylline injection plus compound pholcodine syrup,47 cases)and a monotherapy group(treated with theophylline injection alone,45 cases).The efficacy,time to resolution of clinical symptoms(fever,cough,wheezing,pulmonary rales),and levels of inflammatory factors[granulocyte-macrophage colony-stimulating factor(GM-CSF),C-reactive protein(CRP),soluble interleukin-2 receptor(sIL-2R),tumor necrosis factor-alpha(TNF-α)],and the overall incidence of adverse reactions(constipation,dizziness,dry mouth,nausea)were compared between the two groups.Results:The overall response rate in the combination group was higher than that in the single-agent group,with a statistically significant difference(P＜0.05).The overall incidence of adverse reactions showed no statistically significant difference between the two groups(P＞0.05).Compared with the single-drug group,the combination therapy group demonstrated shorter recovery times for constipation,dizziness,dry mouth,and nausea,along with greater improvements in CRP,sIL-2R,TNF-α,and GM-CSF levels,all with statistically significant differences(P＜0.05).Conclusion:Compound Fucoside Syrup combined with Dose Theophylline Injection demonstrates significant efficacy in treating children with wheezing bronchopneumonia.This combination effectively alleviates clinical symptoms,reduces airway inflammatory responses,promotes recovery,and exhibits fewer side effects.