Efficacy of Extracorporeal Microwave Tumor-Focused Hyperthermia Combined with Corticosteroids in the Treatment of Checkpoint Inhibitor-Related Pneumonia
Wang Guiying
Liu Hanyu
Lu Mingyue
Abstract：Objective:To evaluate the efficacy of extracorporeal microwave tumor-focused hyperthermia combined with corticosteroids in the treatment of checkpoint inhibitor-related pneumonia(CIP).Methods:A total of 66 CIP patients admitted to Jiamusi Tumor Hospital between June 2023 and June 2024 were selected and randomly divided into a control group(corticosteroid therapy,33 cases)and an observation group(corticosteroids plus extracorporeal microwave tumor-focused hyperthermia,33 cases)using a random number table.The therapeutic efficacy,time to symptom/sign resolution,length of hospital stay,incidence of pulmonary fibrosis,Clinical-Radiological-Physiological(CRP)scores,and levels of serum inflammatory cytokines were compared between the two groups.Results:Compared to the control group,the observation group showed a higher overall response rate,shorter resolution times for fever,cough,sputum production,and chest CT lesion disappearance,a reduced length of hospital stay,and a lower incidence of pulmonary fibrosis,after treatment,both groups exhibited decreases in the clinical,radiological,and physiological scores of the CRP scale,as well as in serum levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and high-sensitivity C-reactive protein(hs-CRP),with the observation group demonstrating significantly lower values than the control group(P＜0.05).Conclusion:The combination of extracorporeal microwave tumor-focused hyperthermia with corticosteroid therapy improves efficacy in CIP patients,shortens the time to clinical symptom/sign resolution,reduces the incidence of pulmonary fibrosis,alleviates inflammatory response,and promotes faster recovery.
Keywords：Extracorporeal microwave tumor-focused hyperthermiaCorticosteroidsCheckpoint inhibitor-related pneumoniaPulmonary fibrosis
Publication Date：2026-01-10
Online Publishing Date：2026-03-16(First online date of this platform, not the publication date of the document)
Pages：3( 47-49 )