Correlation Analysis of Serum CA199 Levels with Fasting Blood Glucose and Glycated Hemoglobin in Type 2 Diabetes Patients

Yu Guoqing; Sun Hong

doi:10.3969/j.issn.1004-5775.2025.23.020

Abstract：Objective:To investigate variations in carbohydrate antigen 199(CA199)levels among type 2 diabetes patients with different glycated hemoglobin(HbA1c)levels and to analyze factors associated with CA199 levels.Methods:A retrospective analysis was conducted on the records of 148 patients with type 2 diabetes admitted to Wuhu Conch Hospital from December 2020 to November 2023.Patients were categorized by HbA1c levels into well-controlled glycemia(n=26,HbA1c＜6.5%),moderately controlled glycemia(n=39,HbA1c 6.5%～7.5%),and poorly controlled glycemia(n=83,HbA1c＞7.5%).Fasting blood glucose(FBG),low-density lipoprotein(LDL),triglycerides(TG),high-density lipoprotein(HDL),total cholesterol(TC),and CA199 were measured in each patient group.Differences in blood parameters among the three groups were compared,and the correlation between CA199 and the aforementioned blood parameters was analyzed.Results:The TG,FBG,and CA199 levels in the poor glycemic control group were significantly higher than those in the well-controlled and moderately controlled groups,with statistically significant differences(P＜0.05).The LDL,HDL,and TC levels in the poor glycemic control group showed no statistically significant differences compared with the well-controlled and moderately controlled groups(P＞0.05).Pearson correlation analysis indicated that CA199 was associated with TG,FBG,and HbA1c(r=0.298,0.343,-0.440,P＜0.05).Multivariate linear regression results revealed that FBG and HbA1c are independent risk factors for elevated CA199 levels(β=0.174,0.309,P＜0.05).Conclusion:Poor glycemic control in patients with type 2 diabetes,characterized by elevated FBG and HbA1c levels,may lead to increased serum CA199 levels.