Correlation between Ki-67 and PD-L1 Expression Levels and EGFR Mutation Status in Non-Small Cell Lung Cancer Tissue
Zhao Erchen
Zhou Shumin
Zhang Xuezhen
Abstract：Objective:To investigate the correlation between the expression levels of cell proliferation-associated antigen(Ki-67)and programmed death-ligand 1(PD-L1)in non-small cell lung cancer(NSCLC)tissues and epidermal growth factor receptor(EGFR)mutations.Methods:A total of 155 patients with NSCLC admitted to Zhoukou Central Hospital from June 2022 to December 2023 were enrolled in this study.EGFR mutation status was analyzed,and expression levels of Ki-67 and PD-L1 were detected.Univariate and multivariate logistic regression analyses were performed to determine the correlation between Ki-67 and PD-L1 expression levels and EGFR mutation status.Results:Among 155 patients with NSCLC,EGFR mutations were detected in 77 cases.Multivariate logistic regression analysis revealed that weak ki-67 positivity(OR=2.275)and PD-L1 negativity(OR=2.778)were independent risk factors for EGFR mutation occurrence in NSCLC patients(P＜0.05).Conclusion:The expression levels of Ki-67 and PD-L1 in NSCLC patient tissues are closely associated with EGFR mutations.Clinically,EGFR mutations in NSCLC patients can be identified by detecting weak Ki-67 positivity and PD-L1 negativity.
Keywords：Non-small cell lung cancerProgrammed death ligand 1Cell proliferation-associated antigenEpidermal growth factor receptor mutationCorrelation
Publication Date：2025-12-10
Online Publishing Date：2025-12-31(First online date of this platform, not the publication date of the document)
Pages：3( 2889-2891 )