Clinical Study of Driving Pressure-guided PEEP Titration Combined with Ambroxol on the Efficacy and Impact on Pulmonary Compliance and Inflammatory Mediators in Patients with Acute Respiratory Distress Syndrome
Xu Chunru
Feng Fengyu
Pang Liyong
Abstract：Objective:To explore the clinical efficacy of driving pressure(ΔP)-guided positive end-expiratory pressure(PEEP)titration combined with ambroxol in the treatment of acute respiratory distress syndrome(ARDS)and its effects on pulmonary compliance and inflammatory mediators.Methods:Selecting 60 ARDS patients admitted to Guangdong Suixi People's Hospital from April 2024 to April 2025,they were randomly assigned to the control group(ΔP-guided PEEP)and the observation group(ΔP-guided PEEP combined with ambroxol).The differences in oxygenation,pulmonary compliance,and inflammatory mediators between the two groups were assessed.Results:The observation group showed a significantly higher partial pressure of oxygen(PaO2)/fraction of inspiration(FiO2)ratio,improved pulmonary dynamic compliance,and significantly lower levels of inflammatory markers compared to the control group,with statistically significant differences(P＜0.05).Conclusion:ΔP-guided PEEP titration combined with ambroxol significantly improves oxygenation,enhances pulmonary compliance,and effectively reduces inflammation in ARDS patients,showing promising clinical application prospects.
Keywords：Acute respiratory distress syndromeDriving pressurePositive end-expiratory pressureAmbroxolPulmonary compliance
Publication Date：2025-12-10
Online Publishing Date：2025-12-31(First online date of this platform, not the publication date of the document)
Pages：4( 2860-2863 )