Study on the Predictive Value of Complete Blood Count Index for Missed Early Miscarriage

Liu Dan; Wu Manyu

doi:10.3969/j.issn.1004-5775.2025.23.009

Abstract：Objective:To investigate the predictive value of Complete Blood Count(CBC)index in patients with missed early miscarriage.Methods:Women diagnosed with missed early miscarriage in the Foshan Maternal and Child Health Hospital from September 2021 to August 2022 were randomly selected as the study group,and women with normal pregnancy were selected as the control group.CBC index were collected for all subjects when pregnancy was confirmed the first time,and general clinical data such as age,gestational age at the time of CBC detection and gestational age at the time of termination of pregnancy were collected.The differences of each index between these two groups were compared.Results:The coefficient of variation of red blood cell volume distribution width-coefficient of variation(RDW-CV)and the neutrophil-lymphocyte ratio(NLR)between the missed early miscarriage group and the normal pregnancy group were statistically significant(P＜0.05).Further receiver characteristic curve(ROC)analysis suggested that RDW-CV,NLR and the combined predictor Y could all be used to predict the risk of missed early miscarriage in early pregnancy,and combined predictor Y has higher predictive efficiency.The AUC of combined predictor Y is 0.737,specificity is 53.6%and sensitivity is 81.5%.Conclusion:The predictive power of combined RDW-CV and NLR is better than that of RDW-CV or NLR alone in missed early miscarriage,but the predictive value still needs further in-depth study.