Current Research Status on the Application of Metagenomic Next-Generation Sequencing in Infectious Diseases of the Central Nervous System
Kong Xianzhe
Wei Huan
Jin Furong
Abstract：The central nervous system infection(CNSI)disease carry high rates of disability and mortality worldwide,making accurate early pathogen diagnosis crucial for treatment.However,over half of cases remain undiagnosed using current detection methods,posing significant challenges for clinicians.Metagenomic next-generation sequencing(mNGS)technology,as a novel diagnostic approach characterized by high sensitivity,high throughput,and unbiased detection,has significantly improved pathogen detection rates and holds broad clinical application prospects.It primarily reviews the developmental trajectory of mNGS technology,briefly outlines its clinical applications in pathogen detection for CNSI,and summarizes the challenges and issues it faces.
Keywords：Central nervous system infectionMetagenomic next-generation sequencingPositive rate of pathogensDetection meansClinical applicationCrebrospinal fluid culture
Publication Date：2025-12-10
Online Publishing Date：2025-12-31(First online date of this platform, not the publication date of the document)
Pages：4( 2827-2830 )