Effect of Qingfei Prescription Combined with Oseltamivir Capsuon Patients with Low Fever of Influenza with Heat Toxin Attacking Lung

Guo Yufei; Liu Pan; Xu Hang

doi:10.3969/j.issn.1004-5775.2025.16.020

Abstract：Objective:To observe the effect of Qingfei prescription and Oseltamivir Capsuon on patients with low influenza fever(heat toxin attacking lung type).Methods:60 influenza patients treated in the hospital from January to December 2022 were selected as the subjects.They were divided into control group and observation group by random number table,with 30 patients in each group.The control group took Oseltamivir Phosphate Capsules orally,and the observation group took Qingfei Prescription in combination with Oseltamivir Phosphate Capsules,with a course of treatment lasting for 5 days.The serum indicators[white blood cell(WBC),C-reactive protein(CRP),lymphocyte count(LYM)],body temperature,duration of fever,symptom score,TCM syndrome score,adverse reactions,and safety indicators[serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),blood urea nitrogen(BUN),creatinine(Cr)and total bilirubin(TBIL)]before and after treatment were compared between the two groups.Results:After treatment,the levels of WBC,LYM and CRP in the observation group were significantly lower than those in the control group,and the differences were statistically significant(t=-5.23,-6.82,-4.18;P＜0.001).After the treatment,the body temperature of patients in the observation group was lower than that in the control group,and the difference was statistically significant(t=-1.23,P＜0.05).The duration of fever in the observation group was shorter than that in the control group,and the difference was statistically significant(t=-5.02,P＜0.001).After the treatment,the symptom scores and TCM syndrome scores of the patients in the observation group were significantly lower than those in the control group,and the differences were statistically significant(t=-7.08,-5.10;P＜0.001).No adverse reactions occurred in either group.Conclusion:Qingfei Prescription combined with Oseltamivir Phosphate Capsules have significantly shortened the duration of fever in influenza patients,improved their symptoms,and reduced the level of inflammatory response,with no adverse reactions.