Impact of Sperm DNA Integrity on Embryonic Development and Clinical Outcomes in Infertile Couples Undergoing in Vitro Fertilization Embryo Transfer
Du Wei
Zhao Fang
Zhu Guangli
Abstract：Objective:To explore the impact of sperm DNA integrity on embryonic development and clinical outcomes in infertile couples undergoing in vitro fertilization embryo transfer(IVF-ET)technology.Methods:286 infertile couples who underwent IVF-ET in hospitals from January 2022 to January 2024 were selected as the study subjects.Semen was routine tested and analyzed,and sperm DNA fragmentation index(DFI)was calculated.The study subjects were divided into high DFI group(DFI＞30%)and low DFI group(DFI≤30%)based on sperm DFI.The embryonic development and clinical outcomes of two groups were compared,and the impact of sperm DNA integrity on the embryonic development and clinical outcomes of infertile couples undergoing in vitro fertilization embryo transfer were analyzed.Results:In this study,286 infertile couples were divided into a high DFI group of 83 couples and a low DFI group of 203 couples based on sperm DFI.The fertilization rate,high-quality embryo rate,implantation rate and pregnancy rate of couples in the high DFI group were all lower than those in the low DFI group,and the differences were statistically significant(χ2=4.944,6.865,6.173,7.225;P＜0.05).The results of logistic regression analysis showed that the integrity of sperm DNA had an impact on the embryo development and clinical outcomes of infertile couples undergoing IVF-ET,including the fertilization rate,high-quality embryo rate,implantation rate,and pregnancy rate(OR=1.905,2.008,2.134,2.204;P＜0.05).Conclusion:The integrity of sperm DNA has significant impact on the embryonic development and clinical outcomes of infertile couples undergoing in vitro fertilization embryo transfer.Infertile couples with high male DFI exhibit significant disadvantages in terms of fertilization rate,high-quality embryo rate,implantation rate,and pregnancy rate.Therefore,the level of sperm DNA integrity may be an important predictive factor for the success rate and clinical outcomes of IVF-ET.
Keywords：InfertilityDNAIn vitro fertilization embryo transferEmbryonic development
Publication Date：2025-07-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1725-1727 )