Efficacy and Safety of Ginkgolide B Glucosamine in Patients with Mild to Moderate Cerebral Infarction

Li Huimei; Li Nan; Luo Leiming

doi:10.3969/j.issn.1004-5775.2025.11.003

Abstract：Objective:To evaluate the effects of Ginkgolide B Glucosamine on neurological function,oxidative stress markers and adverse reactions in patients with mild to moderate cerebral infarction.Methods:A total of 84 patients with mild to moderate cerebral infarction treated in the hospital from January 2022 to January 2024 were selected and randomly divided into Group A and Group B,with 42 patients in each group.Group B received conventional treatment,while Group A received Ginkgolide B Glucosamine injections in addition to the conventional treatment.The efficacy,neurological function indicators[brain-specific proteinc S100B,neuron-specific enolase(NSE),and glial fibrillary acidic protein(GFAP)],oxidative stress markers[malondialdehyde(MDA),matrix metalloproteinase-9(MMP-9),glutathione peroxidase(GSH-Px),superoxide dismutase(SOD)],and adverse reactions were compared between the two groups.Results:The total effective rate of group A was higher than that of group B,the difference was statistically significant difference(χ2=4.086,P＜0.05).After 4 weeks of treatment,S100B,NSE and GFAP in group A were higher than those in group B,with statistically significant difference(t=20.715,22.244,12.070;P＜0.05).After 4 weeks of treatment,GSH-Px and SOD levels in group A were higher than those in group B,MDA and MMP-9 levels were lower than those in group B,and the differences were statistically significant(t=7.616,6.390,13.206,2.609;P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(χ2=0.389,P＞0.05).Conclusion:Ginkgolide B Glucosamine combined with conventional treatment can significantly improve neurological function and oxidative stress status in patients with mild to moderate cerebral infarction,and improve the oxidative stress state in patients,with a high safety profile.