Correlation Between Peripheral Blood sIL-2R and IFN-γ,and the Pulmonary Tuberculosis Pathological Characteristics and Disease Progression

Ma Xiaojie; Liu Juan; Li Xiting

doi:10.3969/j.issn.1004-5775.2025.10.019

Abstract：Objective:To investigate the correlation of the expression of peripheral blood interleukin-2 receptor(sIL-2R)and γ Interferon(IFN-γ),and TNF-κ B and pathological characteristics and disease progression of pulmonary tuberculosis.Methods:110 patients with pulmonary tuberculosis admitted from January 2022 to January 2023 in the hospital were selected as the research objects.The sIL-2R and IFN in patients'peripheral blood were determined by enzyme linked immunosorbent assay-sandwich technique.Levels of sIL-2R and IFN-γ in patients with pulmonary tuberculosis with different pathological characteristics were compared.According to the progression of the disease,the enrolled patients were divided into advanced group,improved group,and stable group.And the sIL-2R and IFN-γ of the three groups were compared.Spearman correlation analysis was used to evaluate the correlation between sIL-2R and IFN-γ levels,and the progression of pulmonary tuberculosis.Results:There were differences in the levels of sIL-2R and IFN-γ in pulmonary tuberculosis patients with different pathological characteristics.The levels of sIL-2R and IFN-γ in exudative pulmonary tuberculosis were lower than those in proliferative pulmonary tuberculosis(t=6.174,2.130;P＜0.05),and the levels of sIL-2R and IFN-γ in proliferative pulmonary tuberculosis were lower than those in cheese necrosis.The difference was statistically significant(t=3.375,3.948;P＜0.05).Among the 110 patients with tuberculosis,45 cases were in the advanced stage,30 cases were in the improved stage,and 35 cases were in the stable stage.The levels of sIL-2R and IFN-γ in the advanced stage group were higher than those in the improved stage group,with statistically significant difference(t=9.824,9.173;P＜0.05).The levels of sIL-2R and IFN-γ in the improved stage group were higher than those in the stable stage group.The difference was statistically significant(t=2.860,2.365;P＜0.05).Spearman correlation analysis showed that sIL-2R and IFN-γ levels were negatively correlated with the progression of pulmonary tuberculosis(r=-0.532,-0.587;P＜0.05).Conclusion:There are differences in the levels of sIL-2R and IFN-γ in pulmonary tuberculosis patients with different pathological characteristics.The levels of sIL-2R and IFN-γ are negatively correlated with the progression of pulmonary tuberculosis,and their levels can be used as an important index to determine the pathological characteristics and progression of pulmonary tuberculosis.